AntagoNISTof14.3.3proteins(KD≈80nM).Competitivelyinhibits14.3.3-ligandinteractionswithoutrequiringphosphorylation.BlockstheABIlityof14.3.3tobindtotargetproteinssuchasRaf-1,Bad,ASK1andexoenzymeS.
M.Wt | 2309.69 |
Formula | C101H157N27O29S3 |
Sequence | PHCVPRDLSWLDLEANMCLP |
Storage | Desiccateat-20°C |
CASNumber | 211364-78-2 |
PubChemID | 16138697 |
InChIKey | YSKZRNFKZLWXRG-ZHTKBQOPSA-N |
Smiles | [H]N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solubility | Solubleto1mg/mlinwater |
Thefollowingdataisbasedontheproductmolecularweight2309.69.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 0.43mL | 2.16mL | 4.33mL |
5mM | 0.09mL | 0.43mL | 0.87mL |
10mM | 0.04mL | 0.22mL | 0.43mL |
50mM | 0.01mL | 0.04mL | 0.09mL |