InhibitorofTNF-αreceptor1(TNFR1)signaling;blocksTNFR1associationwithTRADDandRIP1.InhibitsTNF-α-inducedNF-κBandMAPKsignalingpathwayactivation.Attenuatesintracerebralhemorrhage-inducedneurovascularinjuryinmice.
M.Wt | 380.77 |
Formula | C16H8ClF3N4S |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 303997-35-5 |
PubChemID | 1486608 |
InChIKey | SUUMKHOVGVYGOP-UHFFFAOYSA-N |
Smiles | ClC1=CC=C(N=C(SC4=CC=CC=C4)C2=NN=C(C(F)(F)F)N23)C3=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 7.62 | 20 |
Thefollowingdataisbasedontheproductmolecularweight380.77.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.63mL | 13.13mL | 26.26mL |
5mM | 0.53mL | 2.63mL | 5.25mL |
10mM | 0.26mL | 1.31mL | 2.63mL |
50mM | 0.05mL | 0.26mL | 0.53mL |