PositiveallostericmodulatorandallostericagoNISTofthehumancalcium-sensingreceptor(hCaSR).Exhibitscalcimimeticactivity.HastheABIlitytorestorefunctiontohCaSRmutantsthatcausefamilialhypocalciurichypercalcemia(FHH)andneonatalseverehyperparathyroidism(NSHPT).Exertsasuppressiveeffectonparathyroid(PT)hormonesecretion;inhibitsPTcellproliferationinratswithrenalinsufficiency.
R568hydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 340.29 |
Formula | C18H22ClNO.HCl |
Storage | DesiccateatRT |
Purity | ≥99%(HPLC) |
CASNumber | 177172-49-5 |
PubChemID | 158796 |
InChIKey | YJXUXANREVNZLH-PFEQFJNWSA-N |
Smiles | ClC(C=CC=C2)=C2CCCN[C@H](C)C1=CC=CC(OC)=C1.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 34.03 | 100 | |
ethanol | 34.03 | 100 |
Thefollowingdataisbasedontheproductmolecularweight340.29.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.94mL | 14.69mL | 29.39mL |
5mM | 0.59mL | 2.94mL | 5.88mL |
10mM | 0.29mL | 1.47mL | 2.94mL |
50mM | 0.06mL | 0.29mL | 0.59mL |