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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/R 268712/5288/10/10 mg
产品编号:5288/10
市  场 价:¥4700.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$235.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/R 268712/5288/10/10 mg
商品介绍
Description:PotentandselectiveinhibitorofTGF-βRI
ChemicalName:4-[2-Fluoro-5-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]phenyl]-1H-pyrazole-1-ethanol
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentandselectiveinhibitoroftheTGF-βtypeIreceptor/ALK5(IC50=2.5nM).Exhibits~5000-foldselectivityoverp38MAPK.Suppressesdevelopmentofrenalfibrosisinaunilateralureteralobstructionmodel.Alsoreducesproteinuria,glomerulosclerosisandimprovesrenalfunctioninananti-Thy1glomerulonephritismodel.Orallybioavailable.

CompoundLibraries

R268712isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt363.39
FormulaC20H18FN5O
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber879487-87-3
PubChemID11703284
InChIKeyJQGOCCALXFSRHZ-UHFFFAOYSA-N
SmilesOCCN1N=CC(C2=C(F)C=CC(C3=CNN=C3C4=CC=CC(C)=N4)=C2)=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO36.34100
ethanol18.1750

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight363.39.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.75mL13.76mL27.52mL
5mM0.55mL2.75mL5.5mL
10mM0.28mL1.38mL2.75mL
50mM0.06mL0.28mL0.55mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet