GTPaseactivatingproteinofADP-ribosylationfactor1(ARFGAP1)inhibitor.ModulatesARF-GTPlevelsandsynergizeswiththeWnt/β-cateninsignalingpathwaytoupregulateβ-cateninnucleartranslocation.Alsoreducesinvitromigrationofmetastatichumanbreastcancercells.
M.Wt | 567.68 |
Formula | C36H33N5O2 |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 944328-88-5 |
PubChemID | 42623900 |
InChIKey | DOKZLKDGUQWMSX-HKBQPEDESA-N |
Smiles | OC[C@H](CC6=CC=CC=C6)NC1=C2C(N(CC3=CC=C(C7=CC=CC=C7)C=C3)C=N2)=NC(OC4=CC=C(CCC5)C5=C4)=N1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 56.77 | 100 | |
ethanol | 56.77 | 100 |
Thefollowingdataisbasedontheproductmolecularweight567.68.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 1.76mL | 8.81mL | 17.62mL |
5mM | 0.35mL | 1.76mL | 3.52mL |
10mM | 0.18mL | 0.88mL | 1.76mL |
50mM | 0.04mL | 0.18mL | 0.35mL |