GTPaseactivatingproteinofADP-ribosylationfactor1(ARFGAP1)inhibitor.ModulatesARF-GTPlevelsandsynergizeswiththeWnt/β-cateninsignalingpathwaytoupregulateβ-cateninnucleartranslocation.Alsoreducesinvitromigrationofmetastatichumanbreastcancercells.
| M.Wt | 567.68 |
| Formula | C36H33N5O2 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 944328-88-5 |
| PubChemID | 42623900 |
| InChIKey | DOKZLKDGUQWMSX-HKBQPEDESA-N |
| Smiles | OC[C@H](CC6=CC=CC=C6)NC1=C2C(N(CC3=CC=C(C7=CC=CC=C7)C=C3)C=N2)=NC(OC4=CC=C(CCC5)C5=C4)=N1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 56.77 | 100 | |
| ethanol | 56.77 | 100 |
Thefollowingdataisbasedontheproductmolecularweight567.68.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.76mL | 8.81mL | 17.62mL |
| 5mM | 0.35mL | 1.76mL | 3.52mL |
| 10mM | 0.18mL | 0.88mL | 1.76mL |
| 50mM | 0.04mL | 0.18mL | 0.35mL |



