Potentinhibitorofmultidrugandtoxinextrusion(MATE)transporters(Kivaluesare46and77nMforhumanMATE2-K-HEK293andMATE1-HEK293cellsrespectively).Alsoinhibitsdihydrofolatereductase(DHFR)andSTAT3.Decreasesproliferationofhumanautosomaldominantpolycystickidneydiseasecells.
PyrimethamineisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 248.71 |
Formula | C12H13ClN4 |
Storage | StoreatRT |
Purity | ≥99%(HPLC) |
CASNumber | 58-14-0 |
PubChemID | 4993 |
InChIKey | WKSAUQYGYAYLPV-UHFFFAOYSA-N |
Smiles | ClC1=CC=C(C2=C(N)N=C(N)N=C2CC)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 24.87 | 100 | |
ethanol | 2.49 | 10 |
Thefollowingdataisbasedontheproductmolecularweight248.71.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 4.02mL | 20.1mL | 40.21mL |
5mM | 0.8mL | 4.02mL | 8.04mL |
10mM | 0.4mL | 2.01mL | 4.02mL |
50mM | 0.08mL | 0.4mL | 0.8mL |