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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Brequinar sodium/6196/50/50 mg
产品编号:6196/50
市  场 价:¥7980.00
场      地:美国(厂家直采)
产品分类: 蛋白类>>其它酶>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$399.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Brequinar sodium/6196/50/50 mg
商品介绍
Description:Potentandselectivedihydroorotatedehydrogenase(DHODH)inhibitor
AlternativeNames:BRQ,DuP785,NSC368390
ChemicalName:6-Fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-methyl-4-quinolinecarboxylicacidsodium
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potentandselectivedihydroorotatedehydrogenase(DHODH)inhibitor(IC50=~20nM).Causesdepletionofpyrimidinenucleotides.Exhibitsminimalinhibitionagainstapanelof>400kinases.TriggersdifferentiationofAMLcelllines(ED50=~1μM.NoteuridineconcentrationeffectsED50value).Causesdifferentiationanddepletionofleukemia-initiatingcellsinvivo.Antimetabolite.

TechnicalData

M.Wt397.35
FormulaC23H14F2NO2Na
StorageStoreat+4°C
Purity≥99%(HPLC)
CASNumber96201-88-6
PubChemID23663964
InChIKeyPZOHOALJQOFNTB-UHFFFAOYSA-M
SmilesCC1=C(C2=CC(F)=CC=C2N=C1C3=CC=C(C4=C(C=CC=C4)F)C=C3)C(O[Na])=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO39.73100
water39.73100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight397.35.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.52mL12.58mL25.17mL
5mM0.5mL2.52mL5.03mL
10mM0.25mL1.26mL2.52mL
50mM0.05mL0.25mL0.5mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet