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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/ProTx III/5792/100U/100 ug
产品编号:5792/100U
市  场 价:¥4580.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$229.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/ProTx III/5792/100U/100 ug
商品介绍
Description:PotentNav1.7blocker;analgesic
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentNav1.7blocker(IC50=2.5nM).AlsoinhibitsNav1.1,Nav1.2,Nav1.3andNav1.6inthenanomolarrange.ExhibitsnoeffectsonCavchannelsornAChRat5μM.Demonstratesanalgesicactivityinvivo;antagonizeseffectsofscorpion-venomtoxinOD1atNav1.7.

TechnicalData

M.Wt3802.41
FormulaC162H246N52O43S6
SequenceDCLKFGWKCNPRNDKCCSGLKCGSNHNWCKLHI

(Modifications:Disulfidebridge:2-17,9-22,16-29,Ile-33=C-terminalamide)

StorageStoreat-20°C
PubChemID121513895
InChIKeyCLSMEZFRATUESA-ZYYCRPBWSA-N
Smiles[H]N[C@@H](CC(O)=O)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CC4=CNC5=C4C=CC=C5)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC4=CNC=N4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC4=CNC5=C4C=CC=C5)NC(=O)CNC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N3)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H]([C@@H](C)CC)C(O)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolubilitySolubleto1mg/mlinwater

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight3802.41.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM0.26mL1.31mL2.63mL
5mM0.05mL0.26mL0.53mL
10mM0.03mL0.13mL0.26mL
50mM0.01mL0.03mL0.05mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet