mRNAsplicinginhibitor;decreasessplicingcapacityupto75%invitro.Directlytargetssplicesome-associated130(SAP130),inhibitssplicingfactor3Bsubunit(SF3B1)andimpairsU2smallnuclearribonucleoprotein(U2snRNP)interactionwithpre-mRNA.ArrestscellcycleinG1andG2/Mphases.Displaysantitumoractivityagainstgastriccancercells(IC50valuesare1.6-4.9nM).Cellpermeableandactiveinvivo.
M.Wt | 536.7 |
Formula | C30H48O8 |
Storage | Storeat-20°C |
Purity | ≥95%(HPLC) |
CASNumber | 445493-23-2 |
PubChemID | 90909513 |
InChIKey | SDOUORKJIJYJNW-UHFFFAOYSA-N |
Smiles | C[C@@H](/C=C/[C@H](OC(C)=O)[C@](C)(O)CC[C@@H](O)C1)[C@@H](/C(C)=C/C=C/[C@@H](C)C[C@@H]2[C@@H]([C@H](C)[C@@H](O)CC)O2)OC1=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 1 | 2 |
Thefollowingdataisbasedontheproductmolecularweight536.7.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 1.86mL | 9.32mL | 18.63mL |
5mM | 0.37mL | 1.86mL | 3.73mL |
10mM | 0.19mL | 0.93mL | 1.86mL |
50mM | 0.04mL | 0.19mL | 0.37mL |