SyntheticinhibitorofHMG-CoAreductase(Ki=1.7nM).Lowerslow-densitylipoprotein(LDL)cholesterollevels.DisplaysminimalmetabolismbycytochromeP450enzymes,withlittleinvolvementofCYP3A4.Showntoimprovecardiacfunctionandsurvivalinaratmodelofhypertensiveheartfailure.
PitavastatincalciumisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 440.5 |
Formula | C25H23FNO4.0.5Ca |
Storage | DesiccateatRT |
Purity | ≥99%(HPLC) |
CASNumber | 147526-32-7 |
PubChemID | 5282451 |
InChIKey | RHGYHLPFVJEAOC-FFNUKLMVSA-L |
Smiles | [Ca++].O[C@H](C[C@H](O)C=CC1=C(C2=CC=C(F)C=C2)C2=CC=CC=C2N=C1C1CC1)CC([O-])=O.O[C@H](C[C@H](O)C=CC1=C(C2=CC=C(F)C=C2)C2=CC=CC=C2N=C1C1CC1)CC([O-])=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 44.05 | 100 |
Thefollowingdataisbasedontheproductmolecularweight440.5.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.27mL | 11.35mL | 22.7mL |
5mM | 0.45mL | 2.27mL | 4.54mL |
10mM | 0.23mL | 1.14mL | 2.27mL |
50mM | 0.05mL | 0.23mL | 0.45mL |