Inducescelldeathandincreasesthelevelofreactiveoxygenspecies(ROS)incancercellswithbothwild-typeandnormalp53.Alsoinhibitsthegrowthofspontaneousmalignantbreasttumorsinmice.Displayslittleeffectonnormalcells.RapidlydepletesandrogenreceptorexpressioninhumanprostatecancercellsviaaROS-dependent,proteasome-mediatedmechanism.
M.Wt | 317.34 |
Formula | C17H19NO5 |
Storage | Storeat-20°C |
Purity | ≥97%(HPLC) |
CASNumber | 20069-09-4 |
PubChemID | 637858 |
InChIKey | VABYUUZNAVQNPG-BQYQJAHWSA-N |
Smiles | O=C1N(C(/C=C/C2=CC(OC)=C(OC)C(OC)=C2)=O)CCC=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 31.73 | 100 | |
ethanol | 6.35 | 20mMwithgentlewarming |
Thefollowingdataisbasedontheproductmolecularweight317.34.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.15mL | 15.76mL | 31.51mL |
5mM | 0.63mL | 3.15mL | 6.3mL |
10mM | 0.32mL | 1.58mL | 3.15mL |
50mM | 0.06mL | 0.32mL | 0.63mL |