Inhibitsp53bindingtomitochondriabyreducingitsaffinityforantiapoptoticproteinsBcl-2andBcl-XL.Displaysnoeffectonthetransactivationalorcellcyclecheckpointcontrolfunctionofp53.Potentiallyincreasesreprogrammingefficiencyofhumansomaticcellstoinducedpluripotentstemcells(iPSCs)bysilencingp53.Reducescelldeathinducedbyγ-rADIationinvitroandprotectsmicefromdosesofradiationthatcauselethalhematopoieticsyndrome.Selectivelyinhibitsheatshockprotein70(HSP70)activity.
Pifithrin-μisalsoofferedaspartoftheTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 181.21 |
Formula | C8H7NO2S |
Storage | Storeat+4°C |
Purity | ≥99%(HPLC) |
CASNumber | 64984-31-2 |
PubChemID | 327653 |
InChIKey | ZZUZYEMRHCMVTB-UHFFFAOYSA-N |
Smiles | NS(=O)(=O)C#CC1=CC=CC=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 13.12 | 100 | |
ethanol | 13.12 | 100 |
Thefollowingdataisbasedontheproductmolecularweight181.21.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 5.52mL | 27.59mL | 55.18mL |
5mM | 1.1mL | 5.52mL | 11.04mL |
10mM | 0.55mL | 2.76mL | 5.52mL |
50mM | 0.11mL | 0.55mL | 1.1mL |