Cyclicanalogofpifithrin-α(Cat.No.1267),asmallmoleculeinhibitorofp53.Preventsdexamethasone-inducedcelldeathinmurinethymocytes(EC50=2.01μM).Sensitizesp53-deficienttumorstorADIotherapyandchemotherapy;increasesapoptosisintargetcellswhenusedincombinationwithantimicrotubuleagents.
CyclicPifithrin-αhydrobromideisalsoofferedaspartoftheTocriscreenPlusandTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
| M.Wt | 349.29 |
| Formula | C16H16N2S.HBr |
| Storage | DesiccateatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 511296-88-1 |
| PubChemID | 11515812 |
| InChIKey | SGNCOAOESGSEOP-UHFFFAOYSA-N |
| Smiles | CC(C=C4)=CC=C4C1=CN(C2=C(S3)CCCC2)C3=N1.Br |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 34.93 | 100 | |
| ethanol | 3.49 | 10 |
Thefollowingdataisbasedontheproductmolecularweight349.29.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.86mL | 14.31mL | 28.63mL |
| 5mM | 0.57mL | 2.86mL | 5.73mL |
| 10mM | 0.29mL | 1.43mL | 2.86mL |
| 50mM | 0.06mL | 0.29mL | 0.57mL |



