Cyclicanalogofpifithrin-α(Cat.No.1267),asmallmoleculeinhibitorofp53.Preventsdexamethasone-inducedcelldeathinmurinethymocytes(EC50=2.01μM).Sensitizesp53-deficienttumorstorADIotherapyandchemotherapy;increasesapoptosisintargetcellswhenusedincombinationwithantimicrotubuleagents.
CyclicPifithrin-αhydrobromideisalsoofferedaspartoftheTocriscreenPlusandTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 349.29 |
Formula | C16H16N2S.HBr |
Storage | DesiccateatRT |
Purity | ≥98%(HPLC) |
CASNumber | 511296-88-1 |
PubChemID | 11515812 |
InChIKey | SGNCOAOESGSEOP-UHFFFAOYSA-N |
Smiles | CC(C=C4)=CC=C4C1=CN(C2=C(S3)CCCC2)C3=N1.Br |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 34.93 | 100 | |
ethanol | 3.49 | 10 |
Thefollowingdataisbasedontheproductmolecularweight349.29.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.86mL | 14.31mL | 28.63mL |
5mM | 0.57mL | 2.86mL | 5.73mL |
10mM | 0.29mL | 1.43mL | 2.86mL |
50mM | 0.06mL | 0.29mL | 0.57mL |