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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Cyclic Pifithrin-α hydrobromide/3843/10/10 mg
产品编号:3843/10
市  场 价:¥3180.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$159.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Cyclic Pifithrin-α hydrobromide/3843/10/10 mg
商品介绍
Description:p53inhibitor
AlternativeNames:Pifithrin-β
ChemicalName:5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Cyclicanalogofpifithrin-α(Cat.No.1267),asmallmoleculeinhibitorofp53.Preventsdexamethasone-inducedcelldeathinmurinethymocytes(EC50=2.01μM).Sensitizesp53-deficienttumorstorADIotherapyandchemotherapy;increasesapoptosisintargetcellswhenusedincombinationwithantimicrotubuleagents.

CompoundLibraries

CyclicPifithrin-αhydrobromideisalsoofferedaspartoftheTocriscreenPlusandTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt349.29
FormulaC16H16N2S.HBr
StorageDesiccateatRT
Purity≥98%(HPLC)
CASNumber511296-88-1
PubChemID11515812
InChIKeySGNCOAOESGSEOP-UHFFFAOYSA-N
SmilesCC(C=C4)=CC=C4C1=CN(C2=C(S3)CCCC2)C3=N1.Br

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO34.93100
ethanol3.4910

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight349.29.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.86mL14.31mL28.63mL
5mM0.57mL2.86mL5.73mL
10mM0.29mL1.43mL2.86mL
50mM0.06mL0.29mL0.57mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet