Inhibitorofp53;reversIBLyblocksp53-dependenttranscriptionalactivationandapoptosis.Protectsagainstneuronaldeathinmodelsofstrokeandneurodegenerativedisorders.Activeinvivo;protectsmicefromtheside-effectsofcancertherapyassociatedwithp53induction.Supressesself-renewalofembryonicstemcells.Alsoarylhydrocarbonreceptor(AHR)agonist,causesupregulationofAHRtargetgeneCYP1A1(EC50=1.1μM).Cyclicanalogavailable(Cat.No.3843).
Pifithrin-αhydrobromideisalsoofferedaspartoftheTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 367.3 |
Formula | C16H18N2OS.HBr |
Storage | Desiccateat-20°C |
CASNumber | 63208-82-2 |
PubChemID | 9929138 |
InChIKey | HAGVCKULCLQGRF-UHFFFAOYSA-N |
Smiles | Br.CC1=CC=C(C=C1)C(=O)CN1C(=N)SC2=C1CCCC2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 36.73 | 100 |
Thefollowingdataisbasedontheproductmolecularweight367.3.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.72mL | 13.61mL | 27.23mL |
5mM | 0.54mL | 2.72mL | 5.45mL |
10mM | 0.27mL | 1.36mL | 2.72mL |
50mM | 0.05mL | 0.27mL | 0.54mL |