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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Pifithrin-α hydrobromide/1267/10/10 mg
产品编号:1267/10
市  场 价:¥2980.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$149.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Pifithrin-α hydrobromide/1267/10/10 mg
商品介绍
Description:p53inhibitor.AlsoarylhydrocarbonreceptoragoNIST
ChemicalName:1-(4-Methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanonehydrobromide
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Inhibitorofp53;reversIBLyblocksp53-dependenttranscriptionalactivationandapoptosis.Protectsagainstneuronaldeathinmodelsofstrokeandneurodegenerativedisorders.Activeinvivo;protectsmicefromtheside-effectsofcancertherapyassociatedwithp53induction.Supressesself-renewalofembryonicstemcells.Alsoarylhydrocarbonreceptor(AHR)agonist,causesupregulationofAHRtargetgeneCYP1A1(EC50=1.1μM).Cyclicanalogavailable(Cat.No.3843).

CompoundLibraries

Pifithrin-αhydrobromideisalsoofferedaspartoftheTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt367.3
FormulaC16H18N2OS.HBr
StorageDesiccateat-20°C
CASNumber63208-82-2
PubChemID9929138
InChIKeyHAGVCKULCLQGRF-UHFFFAOYSA-N
SmilesBr.CC1=CC=C(C=C1)C(=O)CN1C(=N)SC2=C1CCCC2

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO36.73100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight367.3.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.72mL13.61mL27.23mL
5mM0.54mL2.72mL5.45mL
10mM0.27mL1.36mL2.72mL
50mM0.05mL0.27mL0.54mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet