p53stabilizingagent;preferentiallybindsmutated(Y220C)p53overwild-typep53atasitedistinctfromfunctionalDNA/proteininteractionregions.Slowsrateofthermaldenaturationofp53-Y220C.
PhiKan083isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 274.79 |
Formula | C16H18N2.HCl |
Storage | Storeat+4°C |
Purity | ≥99%(HPLC) |
CASNumber | 880813-36-5 |
PubChemID | 16255105 |
InChIKey | IXWVUPURFWFRNE-UHFFFAOYSA-N |
Smiles | CCN1C3=C(C=CC=C3)C2=C1C=CC(CNC)=C2.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 27.48 | 100 | |
ethanol | 13.74 | 50 | |
water | 13.74 | 50 |
Thefollowingdataisbasedontheproductmolecularweight274.79.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.64mL | 18.2mL | 36.39mL |
5mM | 0.73mL | 3.64mL | 7.28mL |
10mM | 0.36mL | 1.82mL | 3.64mL |
50mM | 0.07mL | 0.36mL | 0.73mL |