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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/PU H71/3104/10/10 mg
产品编号:3104/10
市  场 价:¥4500.00
场      地:美国(厂家直采)
产品分类: 蛋白类>天然蛋白>白蛋白>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$225.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/PU H71/3104/10/10 mg
商品介绍
Description:PotentHsp90inhibitor
ChemicalName:6-Amino-8-[(6-iodo-1,3-benzodioxol-5-yl)thio]-N-(1-methylethyl)-9H-purine-9-propanamine
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potentinhibitorofheatshockprotein90(Hsp90)(IC50=51nMinMDA-MB-468cells).Alsoinhibitscellgrowthinarangeofbreastcancercelllines(IC50valuesare17,31,65,87and140nMforSKBr3,MCF-7,MDA-MB-468,HCC-1806andMDA-MB-231cellsrespectively).Showntoinhibitcellproliferationandinduceapoptosisintriple-negativebreastcancer(TNBC)cells.

TechnicalData

M.Wt512.37
FormulaC18H21IN6O2S
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber873436-91-0
PubChemID9549213
InChIKeySUPVGFZUWFMATN-UHFFFAOYSA-N
SmilesIC1=CC4=C(OCO4)C=C1SC3=NC2=C(N)N=CN=C2N3CCCNC(C)C

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
1eq.HCl51.24100
DMSO51.24100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight512.37.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.95mL9.76mL19.52mL
5mM0.39mL1.95mL3.9mL
10mM0.2mL0.98mL1.95mL
50mM0.04mL0.2mL0.39mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet