Potentinhibitorofheatshockprotein90(Hsp90)(IC50=51nMinMDA-MB-468cells).Alsoinhibitscellgrowthinarangeofbreastcancercelllines(IC50valuesare17,31,65,87and140nMforSKBr3,MCF-7,MDA-MB-468,HCC-1806andMDA-MB-231cellsrespectively).Showntoinhibitcellproliferationandinduceapoptosisintriple-negativebreastcancer(TNBC)cells.
M.Wt | 512.37 |
Formula | C18H21IN6O2S |
Storage | Storeat-20°C |
Purity | ≥98%(HPLC) |
CASNumber | 873436-91-0 |
PubChemID | 9549213 |
InChIKey | SUPVGFZUWFMATN-UHFFFAOYSA-N |
Smiles | IC1=CC4=C(OCO4)C=C1SC3=NC2=C(N)N=CN=C2N3CCCNC(C)C |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
1eq.HCl | 51.24 | 100 | |
DMSO | 51.24 | 100 |
Thefollowingdataisbasedontheproductmolecularweight512.37.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 1.95mL | 9.76mL | 19.52mL |
5mM | 0.39mL | 1.95mL | 3.9mL |
10mM | 0.2mL | 0.98mL | 1.95mL |
50mM | 0.04mL | 0.2mL | 0.39mL |