P-glycoprotein(P-gp)modulator;inhibitsP-gp-mediatedmultidrug-resistance(MDR).Reversesresistancetoseveralcytotoxicdrugsincludingmitoxantroneanddoxorubicin(resistancefactorsare2.0and6.5respectively)inhumanMDRcancercelllines.Non-immunosuppressiveanalogofcyclosporinA(Cat.No.1101).
M.Wt | 1214.62 |
Formula | C63H111N11O12 |
Storage | Storeat-20°C |
Purity | ≥98%(HPLC) |
CASNumber | 121584-18-7 |
PubChemID | 5281884 |
InChIKey | YJDYDFNKCBANTM-QCWCSKBGSA-N |
Smiles | C[C@H](C)[C@@H](C1=O)NC([C@H](CC(C)C)N(C(CN(C([C@H]([C@H](C)C)NC([C@H]([C@]([C@H](C)C/C=C/C)=O)N(C([C@H]([C@@H](C)C)N(C([C@H](CC(C)C)N(C([C@H](CC(C)C)N(C([C@@H](C)NC([C@H](C)NC([C@H](CC(C)C)N1C)=O)=O)=O)C)=O)C)=O)C)=O)C)=O)=O)C)=O)C)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 4.86 | 4 |
Thefollowingdataisbasedontheproductmolecularweight1214.62.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 0.82mL | 4.12mL | 8.23mL |
5mM | 0.16mL | 0.82mL | 1.65mL |
10mM | 0.08mL | 0.41mL | 0.82mL |
50mM | 0.02mL | 0.08mL | 0.16mL |