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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/PSC 833/4042/1/1 mg
产品编号:4042/1
市  场 价:¥4500.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$225.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/PSC 833/4042/1/1 mg
商品介绍
Description:InhibitorofP-gp-mediatedMDR
AlternativeNames:Valspodar
ChemicalName:6-[(2S,4R,6E)-4-methyl-2-(methylamino)-3-oxo-6-octenoicacid]-7-L-valine-cyclosporinA
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

P-glycoprotein(P-gp)modulator;inhibitsP-gp-mediatedmultidrug-resistance(MDR).Reversesresistancetoseveralcytotoxicdrugsincludingmitoxantroneanddoxorubicin(resistancefactorsare2.0and6.5respectively)inhumanMDRcancercelllines.Non-immunosuppressiveanalogofcyclosporinA(Cat.No.1101).

TechnicalData

M.Wt1214.62
FormulaC63H111N11O12
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber121584-18-7
PubChemID5281884
InChIKeyYJDYDFNKCBANTM-QCWCSKBGSA-N
SmilesC[C@H](C)[C@@H](C1=O)NC([C@H](CC(C)C)N(C(CN(C([C@H]([C@H](C)C)NC([C@H]([C@]([C@H](C)C/C=C/C)=O)N(C([C@H]([C@@H](C)C)N(C([C@H](CC(C)C)N(C([C@H](CC(C)C)N(C([C@@H](C)NC([C@H](C)NC([C@H](CC(C)C)N1C)=O)=O)=O)C)=O)C)=O)C)=O)C)=O)=O)C)=O)C)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO4.864

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight1214.62.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM0.82mL4.12mL8.23mL
5mM0.16mL0.82mL1.65mL
10mM0.08mL0.41mL0.82mL
50mM0.02mL0.08mL0.16mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet