Biological Activity
Potent and selective P2Y6 receptor agonist (EC50 values are 70, > 1000 and > 10000 nM for P2Y6, P2Y2 and P2Y4 receptors respectively). Induces contractions of rat isolated intrapulmonary arteries in vitro.
Technical Data
| M. Wt | 566.26 |
| Formula | C17H18N2Na2O13P2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 917567-60-3 |
| PubChem ID | 54591398 |
| InChI Key | LEICCBKKYICWFH-BWBFMJMBSA-L |
| Smiles | [Na+].[Na+].O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP([O-])(=O)OP(O)([O-])=O)N1C=CC(=O)N(CC(=O)C2=CC=CC=C2)C1=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble in water (supplied pre-dissolved at a concentration of 10mM) |
Preparing Stock Solutions
The following data is based on the product molecular weight 566.26. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.77 mL | 8.83 mL | 17.66 mL |
| 5 mM | 0.35 mL | 1.77 mL | 3.53 mL |
| 10 mM | 0.18 mL | 0.88 mL | 1.77 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.35 mL |
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References
References are publications that support the products' biological activity.
El-Tayeb et al (2006) Synthesis and structure-activity relationships of uracil nucleotide derivatives and analogues as agonists at human P2Y2, P2Y4 and P2Y6 receptors. J.Med.Chem. 49 7076 PMID: 17125260
Mitchell et al (2012) Identification of contractile P2Y1, P2Y6, and P2Y12 receptors in rat intrapulmonary artery using selective ligands. J.Pharmacol.Exp.Ther. 343 755 PMID: 22991416
Keywords: PSB 0474, supplier, Potent, selective, P2Y6, agonists, Receptors, Purinergic, purinoceptors, PSB0474, 3-Phenacyl, UDP, disodium, salt, Purinergic, P2Y, Receptors, Purinergic, P2Y, Receptors, Tocris Bioscience
Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。 目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。
Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。
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