Potentandselectivehemeoxygenase1(HO-1)inhibitor(IC50valuesare1.9and>100μMforHO-1andHO-2respectively),reducesproteincarbonylationandreactiveoxygenspeciesformationinadvancedprostatecancercells(PCA).InhibitscellproliferationinvitroandPCAtumorgrowthandlymphnode/lungmetastasesinvivo.SynergizeswithTaxol(Cat.No.1097).
M.Wt | 373.67 |
Formula | C15H17BrN2O2.HCl |
Storage | DesiccateatRT |
Purity | ≥98%(HPLC) |
CASNumber | 939825-12-4 |
PubChemID | 45265865 |
InChIKey | YSOWYXRHOAXXTG-UHFFFAOYSA-N |
Smiles | BrC1=CC=C(C=C1)CCC2(OCCO2)CN3C=CN=C3.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 37.37 | 100 | |
water | 37.37 | 100 |
Thefollowingdataisbasedontheproductmolecularweight373.67.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.68mL | 13.38mL | 26.76mL |
5mM | 0.54mL | 2.68mL | 5.35mL |
10mM | 0.27mL | 1.34mL | 2.68mL |
50mM | 0.05mL | 0.27mL | 0.54mL |