Broadspectrum,reversIBLeDUBinhibitor.Exhibitslimitedactivityagainstotherproteases.Inducesaccumulationofpolyubiquitinatedproteins,buthasnodirectinhibitoryeffectontheproteasome.CytotoxicinHEK293Tandcolorectalcancercells.StABIlizesmicrotubulenetworkinoligodendroglialcells.
M.Wt | 223.28 |
Formula | C7H5N5S2 |
Storage | Storeat-20°C |
Purity | ≥98%(HPLC) |
CASNumber | 2645-32-1 |
PubChemID | 2817763 |
InChIKey | ZXOBLNBVNROVLC-UHFFFAOYSA-N |
Smiles | NC1=C(SC#N)C=C(SC#N)C(N)=N1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 2.23 | 10 |
Thefollowingdataisbasedontheproductmolecularweight223.28.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 4.48mL | 22.39mL | 44.79mL |
5mM | 0.9mL | 4.48mL | 8.96mL |
10mM | 0.45mL | 2.24mL | 4.48mL |
50mM | 0.09mL | 0.45mL | 0.9mL |