Potent,subtype-selectiveestrogenreceptoragonist(EC50~200pM);displays410-foldselectivityforERαoverERβ.Preventsovariectomy-inducedweightgainandlossofbonemineraldensity,andinducesgeneexpressioninthehypothalamusfollowingsystemicadministrationinvivo.
PPTisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 386.45 |
Formula | C24H22N2O3 |
Storage | Storeat+4°C |
Purity | ≥99%(HPLC) |
CASNumber | 263717-53-9 |
PubChemID | 6095481 |
InChIKey | UOSWGERPQQOSHS-UHFFFAOYSA-N |
Smiles | CCCC1=C(N(N=C1C1=CC=C(O)C=C1)C1=CC=C(O)C=C1)C1=CC=C(O)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 38.65 | 100 | |
ethanol | 1.93 | 5 |
Thefollowingdataisbasedontheproductmolecularweight386.45.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.59mL | 12.94mL | 25.88mL |
5mM | 0.52mL | 2.59mL | 5.18mL |
10mM | 0.26mL | 1.29mL | 2.59mL |
50mM | 0.05mL | 0.26mL | 0.52mL |