Potent,subtype-selectiveestrogenreceptoragonist(EC50~200pM);displays410-foldselectivityforERαoverERβ.Preventsovariectomy-inducedweightgainandlossofbonemineraldensity,andinducesgeneexpressioninthehypothalamusfollowingsystemicadministrationinvivo.
PPTisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
| M.Wt | 386.45 |
| Formula | C24H22N2O3 |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 263717-53-9 |
| PubChemID | 6095481 |
| InChIKey | UOSWGERPQQOSHS-UHFFFAOYSA-N |
| Smiles | CCCC1=C(N(N=C1C1=CC=C(O)C=C1)C1=CC=C(O)C=C1)C1=CC=C(O)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 38.65 | 100 | |
| ethanol | 1.93 | 5 |
Thefollowingdataisbasedontheproductmolecularweight386.45.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.59mL | 12.94mL | 25.88mL |
| 5mM | 0.52mL | 2.59mL | 5.18mL |
| 10mM | 0.26mL | 1.29mL | 2.59mL |
| 50mM | 0.05mL | 0.26mL | 0.52mL |



