PotentinhibitorofdipeptidylpeptidaseIV(DPP-IV)(IC50=15.8nM).Displays>1000-foldselectivityforDPP-IVoverDPP-8andDPP-9.Improvesglucosetoleranceinamouseoralglucosetoleranceassay.
PK44phosphateisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
| M.Wt | 527.34 |
| Formula | C17H16F5N7O.H3PO4 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1017682-66-4 |
| PubChemID | 90488917 |
| InChIKey | IRIGBESJZBGJOS-DDWIOCJRSA-N |
| Smiles | N[C@@H](CC(N4CC3=NN=C(C(F)(F)F)N3CC4)=O)CC2=NNC1=C(F)C(F)=CC=C12.OP(O)(O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 52.73 | 100 | |
| water | 52.73 | 100 |
Thefollowingdataisbasedontheproductmolecularweight527.34.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.9mL | 9.48mL | 18.96mL |
| 5mM | 0.38mL | 1.9mL | 3.79mL |
| 10mM | 0.19mL | 0.95mL | 1.9mL |
| 50mM | 0.04mL | 0.19mL | 0.38mL |



