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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/PK 44 phosphate/4145/10/10 mg
产品编号:4145/10
市  场 价:¥5780.00
场      地:美国(厂家直采)
产品分类: 蛋白类>>蛋白酶类>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$289.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/PK 44 phosphate/4145/10/10 mg
商品介绍
Description:PotentandselectivedipeptidylpeptidaseIV(DPP-IV)inhibitor
ChemicalName:(3R)-3-Amino-4-(6,7-difluoro-1H-indazol-3-yl)-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-1-butanonephosphate
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentinhibitorofdipeptidylpeptidaseIV(DPP-IV)(IC50=15.8nM).Displays>1000-foldselectivityforDPP-IVoverDPP-8andDPP-9.Improvesglucosetoleranceinamouseoralglucosetoleranceassay.

CompoundLibraries

PK44phosphateisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt527.34
FormulaC17H16F5N7O.H3PO4
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber1017682-66-4
PubChemID90488917
InChIKeyIRIGBESJZBGJOS-DDWIOCJRSA-N
SmilesN[C@@H](CC(N4CC3=NN=C(C(F)(F)F)N3CC4)=O)CC2=NNC1=C(F)C(F)=CC=C12.OP(O)(O)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO52.73100
water52.73100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight527.34.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.9mL9.48mL18.96mL
5mM0.38mL1.9mL3.79mL
10mM0.19mL0.95mL1.9mL
50mM0.04mL0.19mL0.38mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet