SelectivePIP3antagonist.BlocksthebindingofPIP3tothepleckstrinhomology(PH)domainofAkt(IC50=31.03μM).InhibitscancercellsurvivalandinducesapoptosisbyinhibitionofPIP3-dependentPI3-kinase/Aktsignaling.Exhibitsantitumoractivityinvivo.
M.Wt | 351.76 |
Formula | C14H10ClN3O4S |
Storage | Storeat+4°C |
Purity | ≥99%(HPLC) |
CASNumber | 53501-41-0 |
PubChemID | 3664359 |
InChIKey | RIGXBXPAOGDDIG-UHFFFAOYSA-N |
Smiles | ClC1=C(O)C(NC(NC(C2=CC=CC=C2)=O)=S)=CC([N+]([O-])=O)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 26.38 | 75 | |
ethanol | 3.52 | 10 |
Thefollowingdataisbasedontheproductmolecularweight351.76.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.84mL | 14.21mL | 28.43mL |
5mM | 0.57mL | 2.84mL | 5.69mL |
10mM | 0.28mL | 1.42mL | 2.84mL |
50mM | 0.06mL | 0.28mL | 0.57mL |