SelectivePIP3antagonist.BlocksthebindingofPIP3tothepleckstrinhomology(PH)domainofAkt(IC50=31.03μM).InhibitscancercellsurvivalandinducesapoptosisbyinhibitionofPIP3-dependentPI3-kinase/Aktsignaling.Exhibitsantitumoractivityinvivo.
| M.Wt | 351.76 |
| Formula | C14H10ClN3O4S |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 53501-41-0 |
| PubChemID | 3664359 |
| InChIKey | RIGXBXPAOGDDIG-UHFFFAOYSA-N |
| Smiles | ClC1=C(O)C(NC(NC(C2=CC=CC=C2)=O)=S)=CC([N+]([O-])=O)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 26.38 | 75 | |
| ethanol | 3.52 | 10 |
Thefollowingdataisbasedontheproductmolecularweight351.76.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.84mL | 14.21mL | 28.43mL |
| 5mM | 0.57mL | 2.84mL | 5.69mL |
| 10mM | 0.28mL | 1.42mL | 2.84mL |
| 50mM | 0.06mL | 0.28mL | 0.57mL |



