PotentandselectiveBRPF1bromodomaininhibitor(IC50=80nM).Exhibits>100-foldselectivityforBRPF1overapanelofotherbromodomainsincludingBRPF2(BRD1),BRPF3andBRD4.DisruptsBRPF1bindingtohistoneH3.3.Cellpermeable.
ThisprobeissuppliedinconjunctionwiththeStructuralGenomicsConsortium.Forfurthercharacterizationdetails,pleasevisitthePFI4probesummaryontheSGCwebsite.
PFI4isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
| M.Wt | 380.44 |
| Formula | C21H24N4O3 |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 900305-37-5 |
| PubChemID | 40642506 |
| InChIKey | QCIJLRJBZDBVDB-UHFFFAOYSA-N |
| Smiles | CN(C1=CC(NC(C2=C(OC)C=CC=C2)=O)=C(N3CCCC3)C=C1N4C)C4=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 19.02 | 50 | |
| ethanol | 3.8 | 10 |
Thefollowingdataisbasedontheproductmolecularweight380.44.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.63mL | 13.14mL | 26.29mL |
| 5mM | 0.53mL | 2.63mL | 5.26mL |
| 10mM | 0.26mL | 1.31mL | 2.63mL |
| 50mM | 0.05mL | 0.26mL | 0.53mL |



