PotentandselectiveBRPF1bromodomaininhibitor(IC50=80nM).Exhibits>100-foldselectivityforBRPF1overapanelofotherbromodomainsincludingBRPF2(BRD1),BRPF3andBRD4.DisruptsBRPF1bindingtohistoneH3.3.Cellpermeable.
ThisprobeissuppliedinconjunctionwiththeStructuralGenomicsConsortium.Forfurthercharacterizationdetails,pleasevisitthePFI4probesummaryontheSGCwebsite.
PFI4isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 380.44 |
Formula | C21H24N4O3 |
Storage | Storeat+4°C |
Purity | ≥99%(HPLC) |
CASNumber | 900305-37-5 |
PubChemID | 40642506 |
InChIKey | QCIJLRJBZDBVDB-UHFFFAOYSA-N |
Smiles | CN(C1=CC(NC(C2=C(OC)C=CC=C2)=O)=C(N3CCCC3)C=C1N4C)C4=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 19.02 | 50 | |
ethanol | 3.8 | 10 |
Thefollowingdataisbasedontheproductmolecularweight380.44.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.63mL | 13.14mL | 26.29mL |
5mM | 0.53mL | 2.63mL | 5.26mL |
10mM | 0.26mL | 1.31mL | 2.63mL |
50mM | 0.05mL | 0.26mL | 0.53mL |