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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/PFI 3/5072/10/10 mg
产品编号:5072/10
市  场 价:¥4100.00
场      地:美国(厂家直采)
产品分类: 蛋白类>多肽>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$205.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/PFI 3/5072/10/10 mg
商品介绍
Description:PotentandselectiveSMARCA2/4andpolybromo1inhibitor
ChemicalName:(2E)-1-(2-Hydroxyphenyl)-3-[(1R,4R)-5-(pyridin-2-yl)-2,5-diazABIcyclo[2.2.1]heptan-2-yl]prop-2-en-1-one
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potentandselectivepolybromo1andSMARCA4inhibitor(Kdvaluesare48and89nMrespectively).AlsoinhibitsSMARCA2.Displays30-foldselectivityoverothersub-familybranches.AcceleratesFRAPrecoveryincellsataconcentrationof1μM.

LicensingInformation

ThisprobeissuppliedinconjunctionwiththeStructuralGenomicsConsortium.Forfurthercharacterizationdetails,pleasevisitthePFI3probesummaryontheSGCwebsite.

CompoundLibraries

PFI3isalsoofferedaspartoftheTocriscreenPlusandTocriscreenEpigeneticsToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt321.37
FormulaC19H19N3O2
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber1819363-80-8
PubChemID78243717
InChIKeyINAICWLVUAKEPB-QSTFCLMHSA-N
SmilesO=C(C3=C(O)C=CC=C3)/C=C/N1[C@H](C4)CN(C2=NC=CC=C2)[C@H]4C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO32.14100
ethanol1.615mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight321.37.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM3.11mL15.56mL31.12mL
5mM0.62mL3.11mL6.22mL
10mM0.31mL1.56mL3.11mL
50mM0.06mL0.31mL0.62mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet