PotentBETbromodomaininhibitor;exhibitsinhibitoryactivityatbromodomain-containingprotein(BRD)2andBRD4(IC50valuesare98and220nMrespectively).InducesapoptosisandG1cellcyclearrestinBETinhibitor-sensitivecelllines(MV4;11).AlsodownregulatesAuroraBexpressioninMV4;11cells.Cellpermeable.
ThisprobeissuppliedinconjunctionwiththeStructuralGenomicsConsortium.Forfurthercharacterizationdetails,pleasevisitthePFI1probesummaryontheSGCwebsite.
Chemicalprobes.orgisaportalthatoffersindependentguidanceontheselectionand/orapplicationofsmallmoleculesforresearch.TheuseofPFI1isreviewedonthechemicalprobeswebsite.
PFI1isalsoofferedaspartoftheTocriscreenPlusandTocriscreenEpigeneticsToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 347.39 |
Formula | C16H17N3O4S |
Storage | StoreatRT |
Purity | ≥98%(HPLC) |
CASNumber | 1403764-72-6 |
PubChemID | 71271629 |
InChIKey | TXZPMHLMPKIUGK-UHFFFAOYSA-N |
Smiles | O=C2NC1=CC=C(NS(C3=CC=CC=C3OC)(=O)=O)C=C1CN2C |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 17.37 | 50 |
Thefollowingdataisbasedontheproductmolecularweight347.39.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.88mL | 14.39mL | 28.79mL |
5mM | 0.58mL | 2.88mL | 5.76mL |
10mM | 0.29mL | 1.44mL | 2.88mL |
50mM | 0.06mL | 0.29mL | 0.58mL |