Selectivenon-steroidalandrogenreceptor(AR)antagonist(IC50valuesare26nMand90nMinARbindingassaysandcellularassaysrespectively).Displayslowaffinityforprogesteronereceptor(IC50>10μM).Activeinvivo.
SoldforresearchpurposesunderagreementfromPfizerInc.
M.Wt | 269.26 |
Formula | C14H14F3NO |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 1076225-27-8 |
PubChemID | 25093231 |
InChIKey | MENRRRXHFQYXDW-DGCLKSJQSA-N |
Smiles | O[C@H](CCCC2)[C@H]2[C@]1=CC(C(F)(F)F)=C(C#N)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 26.93 | 100 | |
ethanol | 26.93 | 100 |
Thefollowingdataisbasedontheproductmolecularweight269.26.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.71mL | 18.57mL | 37.14mL |
5mM | 0.74mL | 3.71mL | 7.43mL |
10mM | 0.37mL | 1.86mL | 3.71mL |
50mM | 0.07mL | 0.37mL | 0.74mL |