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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/PF 9184/5917/50/50 mg
产品编号:5917/50
市  场 价:¥15300.00
场      地:美国(厂家直采)
产品分类: 蛋白类>>其它酶>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$765.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/PF 9184/5917/50/50 mg
商品介绍
Description:PotentmicrosomalprostaglandinEsynthase1(mPGES-1)inhibitor
ChemicalName:N-[3',4'-Dichloro(1,1'-biphenyl)-yl]-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide1,1-dioxide
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentmicrosomalprostaglandinEsynthase1(mPGES-1)inhibitor(IC50valuesare16.5and1080nMforhumanandratmPGES-1,respectively).Exhibits>6500-foldselectivityformPGES-1overCOX-1andCOX-2.InhibitsIL-1β-inducedPGE2synthesisinvitro.

LicensingInformation

SoldforresearchpurposesunderagreementfromPfizerInc.

TechnicalData

M.Wt461.32
FormulaC21H14Cl2N2O4S
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber1221971-47-6
PubChemID54728414
InChIKeyVGACSWBJQLLJFB-UHFFFAOYSA-N
SmilesOC2=C(C(NC3=CC=C(C4=CC=C(Cl)C(Cl)=C4)C=C3)=O)NS(C1=CC=CC=C12)(=O)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO46.13100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight461.32.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.17mL10.84mL21.68mL
5mM0.43mL2.17mL4.34mL
10mM0.22mL1.08mL2.17mL
50mM0.04mL0.22mL0.43mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet