HighaffinityandselectiveSmoothened(Smo)receptorantagonist(Ki=4.6nM).Exhibits>1000-foldselectivityforSmooverapanelofotherreceptors,ionchannelsandenzymes.InhibitsShh-inducedHedgehogsignalinginMEFcells.Inducestumorregressioninamedulloblastomaallograftmousemodel.Orallyavailableandbrainpenetrant.
SoldforresearchpurposesunderagreementfromPfizerInc.
PF5274857hydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 473.42 |
Formula | C20H25ClN4O3S.HCl |
Storage | DesiccateatRT |
Purity | ≥98%(HPLC) |
CASNumber | 1613439-62-5 |
PubChemID | 90489027 |
InChIKey | GULNFUQAVPTTQV-UHFFFAOYSA-N |
Smiles | CC1=CN=C(C2=CC(N3CCN(C(CCS(C)(=O)=O)=O)CC3)=NC=C2Cl)C(C)=C1.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 47.34 | 100 | |
water | 47.34 | 100 |
Thefollowingdataisbasedontheproductmolecularweight473.42.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.11mL | 10.56mL | 21.12mL |
5mM | 0.42mL | 2.11mL | 4.22mL |
10mM | 0.21mL | 1.06mL | 2.11mL |
50mM | 0.04mL | 0.21mL | 0.42mL |