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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/PF 5274857 hydrochloride/5262/10/10 mg
产品编号:5262/10
市  场 价:¥4700.00
场      地:美国(厂家直采)
产品分类: 生化试剂>生物分子>受体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$235.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/PF 5274857 hydrochloride/5262/10/10 mg
商品介绍
Description:HighaffinityandselectiveSmoothened(Smo)receptorantagoNIST
ChemicalName:1-[4-(5'-Chloro-3,5-dimethyl[2,4'-bipyridin]-2'-yl-1-piperazinyl]-3-(methylsulfonyl)-1-propanonehydrochloride
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

HighaffinityandselectiveSmoothened(Smo)receptorantagonist(Ki=4.6nM).Exhibits>1000-foldselectivityforSmooverapanelofotherreceptors,ionchannelsandenzymes.InhibitsShh-inducedHedgehogsignalinginMEFcells.Inducestumorregressioninamedulloblastomaallograftmousemodel.Orallyavailableandbrainpenetrant.

LicensingInformation

SoldforresearchpurposesunderagreementfromPfizerInc.

CompoundLibraries

PF5274857hydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt473.42
FormulaC20H25ClN4O3S.HCl
StorageDesiccateatRT
Purity≥98%(HPLC)
CASNumber1613439-62-5
PubChemID90489027
InChIKeyGULNFUQAVPTTQV-UHFFFAOYSA-N
SmilesCC1=CN=C(C2=CC(N3CCN(C(CCS(C)(=O)=O)=O)CC3)=NC=C2Cl)C(C)=C1.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO47.34100
water47.34100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight473.42.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.11mL10.56mL21.12mL
5mM0.42mL2.11mL4.22mL
10mM0.21mL1.06mL2.11mL
50mM0.04mL0.21mL0.42mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet