PotentandselectiveinhibitorofCYP3A4(IC50valuesare0.03,17and70μMforCYP3A4,CYP3A5andCYP3A7respectively).
SoldforresearchpurposesunderagreementfromPfizerInc.
M.Wt | 456.59 |
Formula | C26H32N8 |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 1390637-82-7 |
PubChemID | 71315139 |
InChIKey | WDWIMDKOXZZYHH-FQEVSTJZSA-N |
Smiles | CN1N=C(C5=C(C6=CC=C(C)C=C6)N(C)N=C5)C2=C1N=CN=C2N3C[C@@H](N4CCCCC4)CC3 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 45.66 | 100 | |
ethanol | 9.13 | 20 |
Thefollowingdataisbasedontheproductmolecularweight456.59.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.19mL | 10.95mL | 21.9mL |
5mM | 0.44mL | 2.19mL | 4.38mL |
10mM | 0.22mL | 1.1mL | 2.19mL |
50mM | 0.04mL | 0.22mL | 0.44mL |