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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/PF 3084014 hydrobromide/5751/10/10 mg
产品编号:5751/10
市  场 价:¥3180.00
场      地:美国(厂家直采)
产品分类: 蛋白类>>蛋白酶类>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$159.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/PF 3084014 hydrobromide/5751/10/10 mg
商品介绍
Description:Potentγ-secretaseinhibitor
ChemicalName:(2S)-2-[[(2S)-6,8-Difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]amino]-N-[1-[2-[(2,2-dimethylpropyl)amino]-1,1-dimethylethyl]-1H-imidazol-4-yl]pentanamidedihydrobromide
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potentγ-secretaseinhibitor(IC50valuesare1.2and6.2nMinwholecellandcell-freeassays,respectively).ReducesAβinbrain,CSFandplasmainmiceandguineapigs.

LicensingInformation

SoldforresearchpurposesunderagreementfromPfizerInc.

TechnicalData

M.Wt651.47
FormulaC27H41F2N5O.HBr
StorageDesiccateatRT
Purity≥98%(HPLC)
CASNumber1962925-29-6
PubChemID121513889
InChIKeyLXEYYZYDWLAIPW-KBVFCZPLSA-N
SmilesO=C(NC3=CN(C(C)(C)CNCC(C)(C)C)C=N3)[C@H](CCC)N[C@H]2CCC1=CC(F)=CC(F)=C1C2.Br.Br

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO65.15100
water6.5110mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight651.47.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.53mL7.67mL15.35mL
5mM0.31mL1.53mL3.07mL
10mM0.15mL0.77mL1.53mL
50mM0.03mL0.15mL0.31mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet