Potentγ-secretaseinhibitor(IC50valuesare1.2and6.2nMinwholecellandcell-freeassays,respectively).ReducesAβinbrain,CSFandplasmainmiceandguineapigs.
SoldforresearchpurposesunderagreementfromPfizerInc.
M.Wt | 651.47 |
Formula | C27H41F2N5O.HBr |
Storage | DesiccateatRT |
Purity | ≥98%(HPLC) |
CASNumber | 1962925-29-6 |
PubChemID | 121513889 |
InChIKey | LXEYYZYDWLAIPW-KBVFCZPLSA-N |
Smiles | O=C(NC3=CN(C(C)(C)CNCC(C)(C)C)C=N3)[C@H](CCC)N[C@H]2CCC1=CC(F)=CC(F)=C1C2.Br.Br |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 65.15 | 100 | |
water | 6.51 | 10mMwithgentlewarming |
Thefollowingdataisbasedontheproductmolecularweight651.47.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 1.53mL | 7.67mL | 15.35mL |
5mM | 0.31mL | 1.53mL | 3.07mL |
10mM | 0.15mL | 0.77mL | 1.53mL |
50mM | 0.03mL | 0.15mL | 0.31mL |