PotentandselectiveEP3antagonist(IC50=4.6nM).InhibitsPGE2facilitationofplateletaggregationinvitroandexvivo.DisplaysgoodplasmaandmetabolicstABIlity.Doesnotaffectbleedingtimeinrats.Antiplateletandantithrombotic.
M.Wt | 592.32 |
Formula | C23H15Cl4FN2O3S2 |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 861238-35-9 |
PubChemID | 11296282 |
InChIKey | BFBTVZNKWXWKNZ-HWKANZROSA-N |
Smiles | CC1=CN(C2=C(C=C(C=C12)F)/C=C/C(NS(=O)(C3=CC(Cl)=C(S3)Cl)=O)=O)CC4=C(C=C(C=C4)Cl)Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 59.23 | 100 |
Thefollowingdataisbasedontheproductmolecularweight592.32.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 1.69mL | 8.44mL | 16.88mL |
5mM | 0.34mL | 1.69mL | 3.38mL |
10mM | 0.17mL | 0.84mL | 1.69mL |
50mM | 0.03mL | 0.17mL | 0.34mL |