Acetyl-CoAcarboxylase(ACC)2and1inhibitor(IC50valuesare45and98nM,respectively).Reduceshepaticandskeletalmusclemalonyl-CoAlevelsinrats.Alsoinhibitshepaticdenovolipogenesisandreduceswholebodyrespiratoryexchangeratioinrats.Orallybioavailable.
SoldforresearchpurposesunderagreementfromPfizerInc.
M.Wt | 405.49 |
Formula | C23H27N5O2 |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 1301214-47-0 |
PubChemID | 52934180 |
InChIKey | BDXXSFOJPYSYOC-UHFFFAOYSA-N |
Smiles | O=C(C4=CC=C(N=C(C)N5)C5=C4)N1CCC(CC(C=NN3C(C)C)=C3C(C2)=O)2CC1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 20.27 | 50 | |
ethanol | 8.11 | 20 |
Thefollowingdataisbasedontheproductmolecularweight405.49.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.47mL | 12.33mL | 24.66mL |
5mM | 0.49mL | 2.47mL | 4.93mL |
10mM | 0.25mL | 1.23mL | 2.47mL |
50mM | 0.05mL | 0.25mL | 0.49mL |