SelectiveFGFR1andFGFR3inhibitor(IC50valuesare5,21.5,~100,17600and19800nMforFGFR3,FGFR1,VEGFR2,PDGFRandc-Srcrespectively,and>50000nMforEGFR,InsR,MEKandPKC).InhibitsVEGF-andFGF-inducedangiogenesisinthemousecorneamodelofangiogenesis.InhibitsproliferationanddifferentiationofoligodendrocyteProgenitors.SuppressescellproliferationincelllinesexpressingmutatedFGFR3protein.BlockstumorgrowthinH510andH69SCLCxenograftmodels.
SoldforresearchpurposesunderagreementfromPfizerInc.
PD173074isalsoofferedaspartoftheTocriscreenPlusandTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Thefollowingdataisbasedontheproductmolecularweight523.67.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.