SelectiveFGFR1andFGFR3inhibitor(IC50valuesare5,21.5,~100,17600and19800nMforFGFR3,FGFR1,VEGFR2,PDGFRandc-Srcrespectively,and>50000nMforEGFR,InsR,MEKandPKC).InhibitsVEGF-andFGF-inducedangiogenesisinthemousecorneamodelofangiogenesis.InhibitsproliferationanddifferentiationofoligodendrocyteProgenitors.SuppressescellproliferationincelllinesexpressingmutatedFGFR3protein.BlockstumorgrowthinH510andH69SCLCxenograftmodels.
SoldforresearchpurposesunderagreementfromPfizerInc.
PD173074isalsoofferedaspartoftheTocriscreenPlusandTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 523.67 |
Formula | C28H41N7O3 |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 219580-11-7 |
PubChemID | 1401 |
InChIKey | DXCUKNQANPLTEJ-UHFFFAOYSA-N |
Smiles | O=C(NC(C)(C)C)NC2=NC1=NC(NCCCCN(CC)CC)=NC=C1C=C2C3=CC(OC)=CC(OC)=C3 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 52.37 | 100 | |
ethanol | 52.37 | 100 |
Thefollowingdataisbasedontheproductmolecularweight523.67.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 1.91mL | 9.55mL | 19.1mL |
5mM | 0.38mL | 1.91mL | 3.82mL |
10mM | 0.19mL | 0.95mL | 1.91mL |
50mM | 0.04mL | 0.19mL | 0.38mL |