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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/PD 173074/3044/50/50 mg
产品编号:3044/50
市  场 价:¥16500.00
场      地:美国(厂家直采)
产品分类: 蛋白类>>激酶>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$825.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/PD 173074/3044/50/50 mg
商品介绍
Description:FGFR1and-3inhibitor
ChemicalName:N-[2-[[4-(Diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

SelectiveFGFR1andFGFR3inhibitor(IC50valuesare5,21.5,~100,17600and19800nMforFGFR3,FGFR1,VEGFR2,PDGFRandc-Srcrespectively,and>50000nMforEGFR,InsR,MEKandPKC).InhibitsVEGF-andFGF-inducedangiogenesisinthemousecorneamodelofangiogenesis.InhibitsproliferationanddifferentiationofoligodendrocyteProgenitors.SuppressescellproliferationincelllinesexpressingmutatedFGFR3protein.BlockstumorgrowthinH510andH69SCLCxenograftmodels.

LicensingInformation

SoldforresearchpurposesunderagreementfromPfizerInc.

CompoundLibraries

PD173074isalsoofferedaspartoftheTocriscreenPlusandTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt523.67
FormulaC28H41N7O3
StorageStoreat+4°C
Purity≥98%(HPLC)
CASNumber219580-11-7
PubChemID1401
InChIKeyDXCUKNQANPLTEJ-UHFFFAOYSA-N
SmilesO=C(NC(C)(C)C)NC2=NC1=NC(NCCCCN(CC)CC)=NC=C1C=C2C3=CC(OC)=CC(OC)=C3

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO52.37100
ethanol52.37100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight523.67.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.91mL9.55mL19.1mL
5mM0.38mL1.91mL3.82mL
10mM0.19mL0.95mL1.91mL
50mM0.04mL0.19mL0.38mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet