Tocris/PD 173074/3044/50/50 mg,Tocris,,Tocris,Tocris Bioscience,品牌试剂实验Tocris代理 TOCRIS 4372-10MG,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：Tocris/PD 173074/3044/50/50 mg

产品编号：3044/50

市场价：¥16500.00

场地：美国(厂家直采)

产品分类：蛋白类>酶>激酶>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$825.00

品牌： Tocris

公司：Tocris Bioscience

公司分类：

商品介绍

Description:FGFR1and-3inhibitor

ChemicalName:N-[2-[[4-(Diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

SelectiveFGFR1andFGFR3inhibitor(IC₅₀valuesare5,21.5,~100,17600and19800nMforFGFR3,FGFR1,VEGFR2,PDGFRandc-Srcrespectively,and>50000nMforEGFR,InsR,MEKandPKC).InhibitsVEGF-andFGF-inducedangiogenesisinthemousecorneamodelofangiogenesis.InhibitsproliferationanddifferentiationofoligodendrocyteProgenitors.SuppressescellproliferationincelllinesexpressingmutatedFGFR3protein.BlockstumorgrowthinH510andH69SCLCxenograftmodels.

LicensingInformation

SoldforresearchpurposesunderagreementfromPfizerInc.

CompoundLibraries

PD173074isalsoofferedaspartoftheTocriscreenPlusandTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	523.67
Formula	C₂₈H₄₁N₇O₃
Storage	Storeat+4°C
Purity	≥98%(HPLC)
CASNumber	219580-11-7
PubChemID	1401
InChIKey	DXCUKNQANPLTEJ-UHFFFAOYSA-N
Smiles	O=C(NC(C)(C)C)NC2=NC1=NC(NCCCCN(CC)CC)=NC=C1C=C2C3=CC(OC)=CC(OC)=C3

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	52.37	100
	ethanol	52.37	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight523.67.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.91mL	9.55mL	19.1mL
5mM	0.38mL	1.91mL	3.82mL
10mM	0.19mL	0.95mL	1.91mL
50mM	0.04mL	0.19mL	0.38mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

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