Proliferatingcellnuclearantigen(PCNA)inhibitor.DirectlybindsPCNAtrimers(Kd=0.41μM),reduceschromatin-associatedPCNAincells,inhibitscellgrowththroughinductionofSandG2Marrest,andattenuatesDNAreplicationincells.InhibitsgrowthofarangeoftumorcelllinesinvitrowithIC50valuesinthenanomolartolowmicromolarrange.Inhibitsgrowthofprostatetumorxenograftsinmice.
M.Wt | 310.37 |
Formula | C17H14N2O2S |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 444930-42-1 |
PubChemID | 5410824 |
InChIKey | WNYIQPCMVYAJLQ-JLHYYAGUSA-N |
Smiles | O=C(C1=C(C)C=CS1)N/N=C/C2=C(O)C3=CC=CC=C3C=C2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 31.04 | 100 |
Thefollowingdataisbasedontheproductmolecularweight310.37.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.22mL | 16.11mL | 32.22mL |
5mM | 0.64mL | 3.22mL | 6.44mL |
10mM | 0.32mL | 1.61mL | 3.22mL |
50mM | 0.06mL | 0.32mL | 0.64mL |