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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/PCNA I1/5419/50/50 mg
产品编号:5419/50
市  场 价:¥11700.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$585.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/PCNA I1/5419/50/50 mg
商品介绍
Description:PCNAinhibitor
ChemicalName:N-(3-Methylthiophene-2-carboxylicacid)-N'-[(1-hydroxy-2-naphthalenyl)methylene]hydrazide
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Proliferatingcellnuclearantigen(PCNA)inhibitor.DirectlybindsPCNAtrimers(Kd=0.41μM),reduceschromatin-associatedPCNAincells,inhibitscellgrowththroughinductionofSandG2Marrest,andattenuatesDNAreplicationincells.InhibitsgrowthofarangeoftumorcelllinesinvitrowithIC50valuesinthenanomolartolowmicromolarrange.Inhibitsgrowthofprostatetumorxenograftsinmice.

TechnicalData

M.Wt310.37
FormulaC17H14N2O2S
StorageStoreat+4°C
Purity≥98%(HPLC)
CASNumber444930-42-1
PubChemID5410824
InChIKeyWNYIQPCMVYAJLQ-JLHYYAGUSA-N
SmilesO=C(C1=C(C)C=CS1)N/N=C/C2=C(O)C3=CC=CC=C3C=C2

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO31.04100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight310.37.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM3.22mL16.11mL32.22mL
5mM0.64mL3.22mL6.44mL
10mM0.32mL1.61mL3.22mL
50mM0.06mL0.32mL0.64mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet