Proliferatingcellnuclearantigen(PCNA)inhibitor.DirectlybindsPCNAtrimers(Kd=0.41μM),reduceschromatin-associatedPCNAincells,inhibitscellgrowththroughinductionofSandG2Marrest,andattenuatesDNAreplicationincells.InhibitsgrowthofarangeoftumorcelllinesinvitrowithIC50valuesinthenanomolartolowmicromolarrange.Inhibitsgrowthofprostatetumorxenograftsinmice.
| M.Wt | 310.37 |
| Formula | C17H14N2O2S |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 444930-42-1 |
| PubChemID | 5410824 |
| InChIKey | WNYIQPCMVYAJLQ-JLHYYAGUSA-N |
| Smiles | O=C(C1=C(C)C=CS1)N/N=C/C2=C(O)C3=CC=CC=C3C=C2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.04 | 100 |
Thefollowingdataisbasedontheproductmolecularweight310.37.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.22mL | 16.11mL | 32.22mL |
| 5mM | 0.64mL | 3.22mL | 6.44mL |
| 10mM | 0.32mL | 1.61mL | 3.22mL |
| 50mM | 0.06mL | 0.32mL | 0.64mL |



