AspecificPAFantagonist,morepotentthantheginkolideBN-52021.InhibitsrabbitplateletaggregationwithanIC50valueof1.05μMandhasnosignificantactivityonCa2+channels.Activeinvivo,antagonizingPAF-inducedsystemichypotensionandprotein-plasmaextravasationinrats.
PCA4248isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 361.46 |
Formula | C19H23NO4S |
Storage | Desiccateat-20°C |
Purity | ≥95% |
CASNumber | 123875-01-4 |
PubChemID | 4698 |
InChIKey | DHCNAWNKZMNTIS-UHFFFAOYSA-N |
Smiles | COC(=O)C1=C(C)NC(C)=C(C1C)C(=O)OCCSC1=CC=CC=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 36.14 | 100 | |
ethanol | 36.14 | 100 |
Thefollowingdataisbasedontheproductmolecularweight361.46.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.77mL | 13.83mL | 27.67mL |
5mM | 0.55mL | 2.77mL | 5.53mL |
10mM | 0.28mL | 1.38mL | 2.77mL |
50mM | 0.06mL | 0.28mL | 0.55mL |