RXRantagonist(pA2=7.11).TriggersdissociationofRXRtetramers.AttenuatescellproliferationandinducesapoptosisinMCF-7breastcancercells.
PA452isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 439.59 |
Formula | C26H37N3O3 |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 457657-34-0 |
PubChemID | 9803242 |
InChIKey | JJUUTJCZMGZJDZ-UHFFFAOYSA-N |
Smiles | CC1(C)C2=C(C=C(N(C3=NC=C(C(O)=O)C=N3)C)C(OCCCCCC)=C2)C(C)(C)CC1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 43.96 | 100 | |
ethanol | 4.4 | 10 |
Thefollowingdataisbasedontheproductmolecularweight439.59.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.27mL | 11.37mL | 22.75mL |
5mM | 0.45mL | 2.27mL | 4.55mL |
10mM | 0.23mL | 1.14mL | 2.27mL |
50mM | 0.05mL | 0.23mL | 0.45mL |