Nrf2activator;activatesNrf,whichbindstoantioxidantresponseelements(AREs)andinducesPhase-Iand-IIdrug-metabolizingenzymesincludingCYP2BandNQO1.AlsoincreasesmRNAlevelsofmultiplehepaticxenobiotictransporters.Elevatesexpressionofgenesencodinganti-oxidantandmultidrugresistance-associatedproteins.Displayschemopreventiveactivity.
M.Wt | 226.34 |
Formula | C8H6N2S3 |
Storage | Storeat+4°C |
Purity | ≥99%(HPLC) |
CASNumber | 64224-21-1 |
PubChemID | 47318 |
InChIKey | CKNAQFVBEHDJQV-UHFFFAOYSA-N |
Smiles | CC1=C(SSC1=S)C2=CN=CC=N2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 11.32 | 50 |
Thefollowingdataisbasedontheproductmolecularweight226.34.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 4.42mL | 22.09mL | 44.18mL |
5mM | 0.88mL | 4.42mL | 8.84mL |
10mM | 0.44mL | 2.21mL | 4.42mL |
50mM | 0.09mL | 0.44mL | 0.88mL |