请使用支持JavaScript的浏览器!
主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Obtustatin/4664/100U/100 ug
产品编号:4664/100U
市  场 价:¥5580.00
场      地:美国(厂家直采)
产品分类: 生化试剂>其他>其他试剂>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$279.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Obtustatin/4664/100U/100 ug
商品介绍
Description:Potentandselectiveα1β1inhibitor
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Highlypotentintegrinα1β1inhibitor(IC50=0.8nMforα1β1bindingtotypeIVcollagen).Selectiveforα1β1overα2β1,αIIbβ3,αvβ3,α4β1,α5β6,α9β1andα4β7.InhibitsFGF2-stimulatedangiogenesisinthechickenchorioallantoicmodel.DisplaysantitumorefficacyinasynergisticmousemodelofLewislungcarcinoma;blockshumanmelanomagrowthinnudemice.

TechnicalData

M.Wt4393.07
FormulaC184H284N52O57S8
SequenceCTTGPCCRQCKLKPAGTTCWKTSLTSHYCTGKSCDCPLYPG

(Modifications:Disulfidebridge:1-10,6-29,7-34,19-36)

StorageStoreat-20°C
PubChemID90488962
InChIKeyXXWNADNJWWLFFP-UHFFFAOYSA-N
Smiles[H]N[C@H]1CSSC[C@@H]2NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]3CSSC[C@@H]4NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CSSC[C@H](NC(=O)[C@@H]5CCCN5C(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC1=O)[C@@H](C)O)[C@@H](C)O)C(=O)N3)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CC1=CNC=N1)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC1=CNC3=C1C=CC=C3)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC4=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC2=O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolubilitySolubleto1mg/mlinwater

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight4393.07.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM0.23mL1.14mL2.28mL
5mM0.05mL0.23mL0.46mL
10mM0.02mL0.11mL0.23mL
50mM0mL0.02mL0.05mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet