Highlypotentintegrinα1β1inhibitor(IC50=0.8nMforα1β1bindingtotypeIVcollagen).Selectiveforα1β1overα2β1,αIIbβ3,αvβ3,α4β1,α5β6,α9β1andα4β7.InhibitsFGF2-stimulatedangiogenesisinthechickenchorioallantoicmodel.DisplaysantitumorefficacyinasynergisticmousemodelofLewislungcarcinoma;blockshumanmelanomagrowthinnudemice.
M.Wt | 4393.07 |
Formula | C184H284N52O57S8 |
Sequence | CTTGPCCRQCKLKPAGTTCWKTSLTSHYCTGKSCDCPLYPG (Modifications:Disulfidebridge:1-10,6-29,7-34,19-36) |
Storage | Storeat-20°C |
PubChemID | 90488962 |
InChIKey | XXWNADNJWWLFFP-UHFFFAOYSA-N |
Smiles | [H]N[C@H]1CSSC[C@@H]2NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]3CSSC[C@@H]4NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CSSC[C@H](NC(=O)[C@@H]5CCCN5C(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC1=O)[C@@H](C)O)[C@@H](C)O)C(=O)N3)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CC1=CNC=N1)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC1=CNC3=C1C=CC=C3)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC4=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC2=O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solubility | Solubleto1mg/mlinwater |
Thefollowingdataisbasedontheproductmolecularweight4393.07.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 0.23mL | 1.14mL | 2.28mL |
5mM | 0.05mL | 0.23mL | 0.46mL |
10mM | 0.02mL | 0.11mL | 0.23mL |
50mM | 0mL | 0.02mL | 0.05mL |