Selectivecysteinylleukotrienereceptor1(CysLT1)antagonist(IC50valuesare~4-7and3620nMforCysLT1andCysLT2respectively).Inhibitscontractionofairwaysmoothmuscle,microvascularleakageintoairwaysandeosinophilinfiltration.Candecreasesymptomsofbronchialasthma.
M.Wt | 481.5 |
Formula | C27H23N5O4 |
Storage | Storeat+4°C |
Purity | ≥99%(HPLC) |
CASNumber | 103177-37-3 |
PubChemID | 4887 |
InChIKey | NBQKINXMPLXUET-UHFFFAOYSA-N |
Smiles | O=C2C1=CC=CC(NC(C4=CC=C(OCCCCC5=CC=CC=C5)C=C4)=O)=C1OC(C3=NN=NN3)=C2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 24.07 | 50 |
Thefollowingdataisbasedontheproductmolecularweight481.5.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.08mL | 10.38mL | 20.77mL |
5mM | 0.42mL | 2.08mL | 4.15mL |
10mM | 0.21mL | 1.04mL | 2.08mL |
50mM | 0.04mL | 0.21mL | 0.42mL |