SelectiveBRPF1BandBRPF2bromodomaininhibitor(Kdvaluesare100and500nMrespectively).Exhibits39-foldselectivityforBRPF1BandBRPF2overBRD4.AcceleratesFRAPrecoveryat5μMinaBRPF2FRAPassay.
ThisprobeissuppliedinconjunctionwiththeStructuralGenomicsConsortium.Forfurthercharacterizationdetails,pleasevisittheOF1probesummaryontheSGCwebsite.
OF1isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 440.31 |
Formula | C17H18BrN3O4S |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 919973-83-4 |
PubChemID | 35397514 |
InChIKey | YUNQZQREIHWDQT-UHFFFAOYSA-N |
Smiles | CN1C2=C(C=C(OC)C(NS(C3=C(C)C=C(Br)C=C3)(=O)=O)=C2)N(C)C1=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 8.81 | 20 |
Thefollowingdataisbasedontheproductmolecularweight440.31.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.27mL | 11.36mL | 22.71mL |
5mM | 0.45mL | 2.27mL | 4.54mL |
10mM | 0.23mL | 1.14mL | 2.27mL |
50mM | 0.05mL | 0.23mL | 0.45mL |