Oct4activator.EnhancesandacceleratesiPSCreprogramminginthepresenceof4F(Oct4,Sox2,c-MycandKlf4)by~20-foldcomparedto4Falone.InducesmRNAexpressionofOct4,Sox2andNanogandalsoTet1.Displaysnoeffectsonp53-p21pathwayorWnt-β-cateninsignaling.
OAC-1isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 237.26 |
Formula | C14H11N3O |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 300586-90-7 |
PubChemID | 789882 |
InChIKey | HWJRIFZDXJKJJN-UHFFFAOYSA-N |
Smiles | O=C(C3=CC=CC=C3)NC1=NC=C2C(C=CN2)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 23.73 | 100 | |
ethanol | 23.73 | 100 |
Thefollowingdataisbasedontheproductmolecularweight237.26.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 4.21mL | 21.07mL | 42.15mL |
5mM | 0.84mL | 4.21mL | 8.43mL |
10mM | 0.42mL | 2.11mL | 4.21mL |
50mM | 0.08mL | 0.42mL | 0.84mL |