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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Noscapine hydrochloride/1697/100/100 mg
产品编号:1697/100
市  场 价:¥1900.00
场      地:美国(厂家直采)
产品分类: 生化试剂>其他>其他试剂>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$95.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Noscapine hydrochloride/1697/100/100 mg
商品介绍
Description:Tubulininhibitor;inducesapoptosis
ChemicalName:(3S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-1(3H)-isobenzofuranonehydrochloride
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Opioidalkaloidwithseveralactions.Bindstotubulin,arrestscellsinmitosisandinducesapoptosis.AntagoNISTatbradykininreceptors(pA2=6.68),inhibitscarbachol-stimulatedphosphoinositolturnoverandenhancesforskolin-stimulatedcAMPincreasesinCNStissues.ModulatesIKKactivation,suppressingtheNF-κBsignalingpathway.Blocksproliferationofhumanleukemiaandmultiplemyelomacells.Exhibitsanti-inflammatoryactivity.

TechnicalData

M.Wt449.88
FormulaC22H23NO7.HCl
StorageDesiccateatRT
Purity≥99%(HPLC)
CASNumber912-60-7
PubChemID442329
InChIKeyMFLVZFXCSKVCSH-URBRKQAFSA-N
SmilesO=C2C1=C(OC)C(OC)=CC=C1[C@]([C@]3([H])N(CCC4=C3C(OC)=C5C(OCO5)=C4)C)([H])O2.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
1eq.HCl22.4950
DMSO44.99100
ethanol4.510mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight449.88.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.22mL11.11mL22.23mL
5mM0.44mL2.22mL4.45mL
10mM0.22mL1.11mL2.22mL
50mM0.04mL0.22mL0.44mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet