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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Nogo-66 (1-40)/1984/1/1 mg
产品编号:1984/1
市  场 价:¥6700.00
场      地:美国(厂家直采)
产品分类: 生化试剂>其他>其他试剂>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$335.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Nogo-66 (1-40)/1984/1/1 mg
商品介绍
Description:CompetitiveantagoNISTforNogo-66receptor;promotesneuronregeneration
AlternativeNames:NEP1-40,NogoExtracellularPeptide,1-40
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Peptidefragmentcorrespondingtoresidues1-40ofNogo-66,thedomainofthemyelinproteinNogothatinhibitsaxonaloutgrowth.ActsasacompetitiveantagonistattheNogo-66receptor(NgR);blocksNogo-66-andCNSmyelin-inducedinhibitionofaxonalgrowth,butdoesnotreducemyelin-associatedglycoprotein(MAG)inhibitionofneuriteoutgrowthinvitro.Promotesregenerationofhemisectedspinalaxonsandlocomotorrecoveryfollowingspinalinjuryinvivo.

TechnicalData

M.Wt4625.16
FormulaC206H324N56O65
SequenceRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS

(Modifications:Arg-1=N-terminalAc,Ser-40=C-terminalamide)

StorageDesiccateat-20°C
CASNumber475221-20-6
PubChemID16142739
InChIKeyOLEKMOOQFWTQGD-SJQNMCRDSA-N
SmilesCC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC1=CNC=N1)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(C)=O)[C@@H](C)CC)C(C)C)[C@@H](C)CC)[C@@H](C)CC)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(N)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolubilitySolubleto1mg/mlinwater

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight4625.16.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM0.22mL1.08mL2.16mL
5mM0.04mL0.22mL0.43mL
10mM0.02mL0.11mL0.22mL
50mM0mL0.02mL0.04mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet