Peptidefragmentcorrespondingtoresidues1-40ofNogo-66,thedomainofthemyelinproteinNogothatinhibitsaxonaloutgrowth.ActsasacompetitiveantagonistattheNogo-66receptor(NgR);blocksNogo-66-andCNSmyelin-inducedinhibitionofaxonalgrowth,butdoesnotreducemyelin-associatedglycoprotein(MAG)inhibitionofneuriteoutgrowthinvitro.Promotesregenerationofhemisectedspinalaxonsandlocomotorrecoveryfollowingspinalinjuryinvivo.
M.Wt | 4625.16 |
Formula | C206H324N56O65 |
Sequence | RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS (Modifications:Arg-1=N-terminalAc,Ser-40=C-terminalamide) |
Storage | Desiccateat-20°C |
CASNumber | 475221-20-6 |
PubChemID | 16142739 |
InChIKey | OLEKMOOQFWTQGD-SJQNMCRDSA-N |
Smiles | CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC1=CNC=N1)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(C)=O)[C@@H](C)CC)C(C)C)[C@@H](C)CC)[C@@H](C)CC)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(N)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solubility | Solubleto1mg/mlinwater |
Thefollowingdataisbasedontheproductmolecularweight4625.16.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 0.22mL | 1.08mL | 2.16mL |
5mM | 0.04mL | 0.22mL | 0.43mL |
10mM | 0.02mL | 0.11mL | 0.22mL |
50mM | 0mL | 0.02mL | 0.04mL |