Non-steroidalandsilentantiandrogen.Bindstoandrogenreceptorsandalsoinhibitsandrogenbiosynthesisinvitro.Inratsinvivoitinhibitsandrogen-inducedprostateweightincreaseandinhibitsnegativeandrogen-dependentgonadotropinfeedbackleADIngtoanincreaseinluteinisinghormoneandtestosterone.Orallyactive.
M.Wt | 317.22 |
Formula | C12H10F3N3O4 |
Storage | StoreatRT |
Purity | ≥99%(HPLC) |
CASNumber | 63612-50-0 |
PubChemID | 4493 |
InChIKey | XWXYUMMDTVBTOU-UHFFFAOYSA-N |
Smiles | CC1(C)NC(=O)N(C1=O)C1=CC=C(C(=C1)C(F)(F)F)N(=O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 7.93 | 25 | |
ethanol | 7.93 | 25mMwithgentlewarming |
Thefollowingdataisbasedontheproductmolecularweight317.22.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.15mL | 15.76mL | 31.52mL |
5mM | 0.63mL | 3.15mL | 6.3mL |
10mM | 0.32mL | 1.58mL | 3.15mL |
50mM | 0.06mL | 0.32mL | 0.63mL |