Bindsthetransactivationresponseelement(TAR)ofHIV-1(Kd=1.35μM)andinhibitsitsinteractionwithTat.Exhibits>35-foldselectivityforHIV-1TARoverHIV-2TARorA-siteandRRERNA.InhibitsTat-mediatedHIV-1activationandreplicationinT-cellsinvitro.Alsosemisyntheticaminoglycosideantibiotic.
M.Wt | 720.78 |
Formula | C21H41N5O7.2.5H2SO4 |
Storage | DesiccateatRT |
CASNumber | 56391-57-2 |
PubChemID | 62115 |
InChIKey | AGFWIZQEWFGATK-UNZHCMSXSA-N |
Smiles | OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.[H][C@@]1(OC(CN)=CC[C@H]1N)O[C@@H]2[C@H](C[C@H]([C@@H]([C@H]2O)O[C@]3(OC[C@](O)([C@@H]([C@H]3O)NC)C)[H])NCC)N.[H][C@@]4(OC(CN)=CC[C@H]4N)O[C@@H]5[C@H](C[C@H]([C@@H]([C@H]5O)O[C@]6(OC[C@](O)([C@@H]([C@H]6O)NC)C)[H])NCC)N |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
water | 72.08 | 100 |
Thefollowingdataisbasedontheproductmolecularweight720.78.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 1.39mL | 6.94mL | 13.87mL |
5mM | 0.28mL | 1.39mL | 2.77mL |
10mM | 0.14mL | 0.69mL | 1.39mL |
50mM | 0.03mL | 0.14mL | 0.28mL |