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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Netilmicin sulfate/6339/10/10 mg
产品编号:6339/10
市  场 价:¥4100.00
场      地:美国(厂家直采)
产品分类: 其它>其它试剂>临床研究>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$205.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Netilmicin sulfate/6339/10/10 mg
商品介绍
Description:InhibitsHIV-1replication;alsosemisyntheticaminoglycosideantibiotic
ChemicalName:O-3-Deoxy-4-C-methyl-3-(methylamino)-β-L-arABInopyranosyl-(1-6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-a-D-glycero-hex-4-enopyranosyl-(1-4)]-2-deoxy-N1-ethyl-D-streptaminesestersulfate
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Bindsthetransactivationresponseelement(TAR)ofHIV-1(Kd=1.35μM)andinhibitsitsinteractionwithTat.Exhibits>35-foldselectivityforHIV-1TARoverHIV-2TARorA-siteandRRERNA.InhibitsTat-mediatedHIV-1activationandreplicationinT-cellsinvitro.Alsosemisyntheticaminoglycosideantibiotic.

TechnicalData

M.Wt720.78
FormulaC21H41N5O7.2.5H2SO4
StorageDesiccateatRT
CASNumber56391-57-2
PubChemID62115
InChIKeyAGFWIZQEWFGATK-UNZHCMSXSA-N
SmilesOS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.[H][C@@]1(OC(CN)=CC[C@H]1N)O[C@@H]2[C@H](C[C@H]([C@@H]([C@H]2O)O[C@]3(OC[C@](O)([C@@H]([C@H]3O)NC)C)[H])NCC)N.[H][C@@]4(OC(CN)=CC[C@H]4N)O[C@@H]5[C@H](C[C@H]([C@@H]([C@H]5O)O[C@]6(OC[C@](O)([C@@H]([C@H]6O)NC)C)[H])NCC)N

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
water72.08100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight720.78.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.39mL6.94mL13.87mL
5mM0.28mL1.39mL2.77mL
10mM0.14mL0.69mL1.39mL
50mM0.03mL0.14mL0.28mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet